Selected Publications
Ken-ichi Yano and Keiko Morotomi-Keiko
Cell stress responses to pulsed electric fields.
Handbook of Electroporation, Second edition, Springer-Nature, in press, 2024
Keiko Morotomi-Yano, Shinya Hayami, Ken-ichi Yano
Adhesion states greatly affect cellular susceptibility to graphene oxide: therapeutic implications for cancer metastasis.
International Journal of Molecular Sciences, Vol 25, Article number 1927, 2024
Keiko Morotomi-Yano, Yukiko Hiromoto, Takumi Higaki, Ken-ichi Yano
Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ.
Scientific Reports, Vol 12, Article number: 20627, 2022
Keiko Morotomi-Yano and Ken-ichi Yano
Nucleolar translocation of human DNA topoisomerase II by ATP depletion and its disruption by the RNA polymerase I inhibitor BMH-21.
Scientific Reports, Vol 11, Article number: 21533, 2021
Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-ichi Yano
Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells.
Scientific Reports, Vol 9, Article number: 8451, 2019
Keiko Morotomi-Yano, Shinta Saito, Noritaka Adachi, Ken-ichi Yano
Dynamic behavior of DNA topoisomerase IIβ in response to DNA double-strand breaks.
Scientific Reports, Vol 8, Article number: 10344, 2018
Gizem Gülevin Takir, Yuki Ohsaki, Keiko Morotomi-Yano, Ken-ichi Yano, Hisato Saitoh
Linkage between lipid droplet formation and nuclear deformation in HeLa human cervical cancer cells.
Biochemical and Biophysical Research Communications, Vol 504, pp 485-490, 2018
Keiko Morotomi-Yano and Ken-ichi Yano
Calcium-dependent activation of transglutaminase 2 by nanosecond pulsed electric fields.
FEBS Open Bio, Vol 7, pp 934-943, 2017
Ken-ichi Yano and Keiko Morotomi-Yano
Phosphorylation-mediated control of stress responses induced by nanosecond pulsed electric fields.
in Protein Phosphorylation (Editor: Claude Prigent, InTech Open, Croatia, ISBN 978-953-51-5365-8) pp 97-114, 2017
Ken-ichi Yano and Keiko Morotomi-Yano
Cellular Stress Responses to Pulsed Electric Fields.
in Handbook of Electroporation (Editor: Damijan Miklavcic, Springer International Publishing, Switzerland, DOI 10.1007/978-3-319-26779-1_17-1) pp 289-305, 2017
Ken-ichi Yano and Keiko Morotomi-Yano
Intracellular signaling pathways activated by nanosecond pulsed electric fields.
in Bioelectrics (Eds. Hidenori Akiyama and Richard Heller, ISBN 978-4-431-56095-1, Springer International Publishing, Switzerland) pp 219-227, 2017
Tomofumi Nakayama, Noriko Saitoh, Keiko Morotomi-Yano, Ken-ichi Yano, Mitsuyoshi Nakao, Hisato Saitoh
Nuclear extrusion precedes discharge of genomic DNA fibers during tunicamycin-induced neutrophil extracellular trap-osis (NETosis)-like cell death in cultured human leukemia cells.
Cell Biology International, Vol 40, pp 597-602, 2016
Keiko Morotomi-Yano, Hidenori Akiyama, Ken-ichi Yano
Different involvement of extracellular calcium in two modes of cell death induced by nanosecond pulsed electric fields.
Archives of Biochemistry and Biophysics, Vol 555-556, pp 47-54, 2014
Keiko Morotomi-Yano, Hidenori Akiyama, Ken-ichi Yano
Nanosecond pulsed electric fields induce poly(ADP-ribose) formation and non-apoptotic cell death in HeLa S3 cells.
Biochemical and Biophysical Research Communications, Vol 438, pp 557-562, 2013
Keiko Morotomi-Yano, Hidenori Akiyama, Ken-ichi Yano
Nanosecond pulsed electric fields activate AMP-activated protein kinase: Implications for calcium-mediated activation of cellular signaling.
Biochemical and Biophysical Research Communications, Vol 428, pp 371-375, 2012
Keiko Morotomi-Yano, Seiichi Oyadomari, Hidenori Akiyama, Ken-ichi Yano
Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2alpha phosphorylation and 4E-BP1 dephosphorylation.
Experimental Cell Research, Vol 318, pp 1733-1744, 2012
Keiko Morotomi-Yano, Hidenori Akiyama, Ken-ichi Yano
Nanosecond pulsed electric fields activate MAPK pathways in human cells.
Archives of Biochemistry and Biophysics, Vol 515, pp 99-106, 2011
Keiko Morotomi-Yano, Yuichi Uemura, Sunao Katsuki, Hidenori Akiyama, Ken-ichi Yano
Activation of the JNK pathway by nanosecond pulsed electric fields.
Biochemical and Biophysical Research Communications, Vol 408, pp 471-476, 2011
Selected Presentations
Ken-ichi Yano
Ultrashort electric pulse as a novel physical method for medicine
International Conference on Health Innovation 2023, Surabaya, Indonesia, July 26, 2023
Invited talk
Koki Mochizuki, Tsubasa Koga, Keiko Morotomi-Yano, Ken-ichi Yano
Activation of neutrophils by nanosecond pulsed electric fields
19th International Conference on Flow Dynamics, Sendai, Miyagi, November 9, 2022
Ken-ichi Yano and Keiko Morotomi-Yano
Molecular mechanisms for cell death induction by nanosecond pulsed electric fields -
13rd International Conference on Flow Dynamics (ICFD2016), Sendai, Japan, Oct 11, 2016
Invited talk
Ken-ichi Yano and Keiko Morotomi-Yano
Molecular mechanisms underlying cellular responses to nanosecond pulsed electric fields -
1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies, Portoroz, Slovenia, Sep 7, 2015
Plenary talk
Ken-ichi Yano and Keiko Morotomi-Yano
Physiological significance of calcium in cellular responses to nanosecond pulsed electric fields -
The Annual Meeting of Bioelectromagnetics Society European Bioelectromagnetics Association (BioEM 2015), Pacific Grove, CA, USA, June 19, 2015
Plenary talk
Ken-ichi Yano and Keiko Morotomi-Yano
Molecular basis of cellular responses to nanosecond pulsed electric fields - signal transduction, stress response, and cell death -
11th International Conference on Flow Dynamics, Sendai, Japan, Oct 10, 2014
Plenary talk
Ken-ichi Yano and Keiko Morotomi-Yano
Molecular mechanisms underlying cellular responses to nanosecond pulsed electric fields - Signal transduction, stress response, and cell death -
International Workshop on Diagnostics and Modelling for Plasma Medicine (DMPM2014), Nara, Japan, May 23, 2014
Invited talk
Ken-ichi Yano and Keiko Morotomi-Yano
Adaptive responses of human cells to nanosecond pulsed electric fields
Bioelectrochemistry 2013 (12th Topical Meeting of the International Society of Electrochemistry & XXII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society), Bochum, Germany, Mar 19, 2013
Plenary talk
Ken-ichi Yano
Nanosecond pulsed electric fields act as a novel form of cellular stress to induce translational suppression in human cells.
Gordon Research Conference on Bioelectrochemistry, Lucca, Italy, Jul 2, 2012
Invited talk
Ken-ichi Yano and Keiko Morotomi Yano
Molecular mechanism underlying biological responses to nanosecond pulsed electric fields.
International Bioelectrics Symposium 2011, Toulouse, France, May 5, 2011
Plenary talk
Ken-ichi Yano, Keiko Morotomi-Yano, and David J. Chen
Real-time imaging reveals a novel view of protein assembly in the non-homologous end-joining pathway.
The 56th Annual Meeting of the Radiation Research Society, Maui, Hawaii, USA, Sep 28, 2010
Invited talk
