Selected Publications
Manato Mitsui, Keiko Morotomi-Yano, Ken-ichi Yano
Epithelial–mesenchymal transition increases the susceptibility of human A549 cells to nanosecond pulsed electric fields.
International Journal of Molecular Sciences Vol 26, No 23, Article Number 11360, 2025
Keiko Morotomi-Yano and Ken-ichi Yano
Aclarubicin reduces the nuclear mobility of human DNA topoisomerase IIβ.
International Journal of Molecular Sciences Vol 25, No 19, Article Number 10681, 2024
Airi Nakayama, Siwei Liu, Ken-ichi Yano, Tomoki Nakajima, Takehiko Sato
Cellular response to plasma-generated electrical and chemical stimulation of equal electricity.
Journal of Physics D: Applied Physics Vol 57, No 41, Article Number 415202, 2024
Keiko Morotomi-Yano, Shinya Hayami, Ken-ichi Yano
Adhesion states greatly affect cellular susceptibility to graphene oxide: therapeutic implications for cancer metastasis.
International Journal of Molecular Sciences, Vol 25, Article number 1927, 2024
Hayato Tada, Satoshi Uehara, Chia-Hsing Chang, Ken-ichi Yano, Takehiko Sato
Effect of nanosecond pulsed currents on directions of cell elongation and migration through time-lapse analysis.
International Journal of Molecular Sciences Vol 24, No 4, Article Number 3826, 2023
Keiko Morotomi-Yano, Yukiko Hiromoto, Takumi Higaki, Ken-ichi Yano
Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ.
Scientific Reports, Vol 12, Article number: 20627, 2022
Keiko Morotomi-Yano and Ken-ichi Yano
Nucleolar translocation of human DNA topoisomerase II by ATP depletion and its disruption by the RNA polymerase I inhibitor BMH-21.
Scientific Reports, Vol 11, Article number: 21533, 2021
Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-ichi Yano
Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells.
Scientific Reports, Vol 9, Article number: 8451, 2019
Keiko Morotomi-Yano, Shinta Saito, Noritaka Adachi, Ken-ichi Yano
Dynamic behavior of DNA topoisomerase IIβ in response to DNA double-strand breaks.
Scientific Reports, Vol 8, Article number: 10344, 2018
Gizem Gülevin Takir, Yuki Ohsaki, Keiko Morotomi-Yano, Ken-ichi Yano, Hisato Saitoh
Linkage between lipid droplet formation and nuclear deformation in HeLa human cervical cancer cells.
Biochemical and Biophysical Research Communications, Vol 504, pp 485-490, 2018
Keiko Morotomi-Yano and Ken-ichi Yano
Calcium-dependent activation of transglutaminase 2 by nanosecond pulsed electric fields.
FEBS Open Bio, Vol 7, pp 934-943, 2017
Ken-ichi Yano and Keiko Morotomi-Yano
Phosphorylation-mediated control of stress responses induced by nanosecond pulsed electric fields.
in Protein Phosphorylation (Editor: Claude Prigent, InTech Open, Croatia, ISBN 978-953-51-5365-8) pp 97-114, 2017
Ken-ichi Yano and Keiko Morotomi-Yano
Cellular Stress Responses to Pulsed Electric Fields.
in Handbook of Electroporation (Editor: Damijan Miklavcic, Springer International Publishing, Switzerland, DOI 10.1007/978-3-319-26779-1_17-1) pp 289-305, 2017
Ken-ichi Yano and Keiko Morotomi-Yano
Intracellular signaling pathways activated by nanosecond pulsed electric fields.
in Bioelectrics (Eds. Hidenori Akiyama and Richard Heller, ISBN 978-4-431-56095-1, Springer International Publishing, Switzerland) pp 219-227, 2017
Tomofumi Nakayama, Noriko Saitoh, Keiko Morotomi-Yano, Ken-ichi Yano, Mitsuyoshi Nakao, Hisato Saitoh
Nuclear extrusion precedes discharge of genomic DNA fibers during tunicamycin-induced neutrophil extracellular trap-osis (NETosis)-like cell death in cultured human leukemia cells.
Cell Biology International, Vol 40, pp 597-602, 2016
Keiko Morotomi-Yano, Hidenori Akiyama, Ken-ichi Yano
Different involvement of extracellular calcium in two modes of cell death induced by nanosecond pulsed electric fields.
Archives of Biochemistry and Biophysics, Vol 555-556, pp 47-54, 2014
Keiko Morotomi-Yano, Hidenori Akiyama, Ken-ichi Yano
Nanosecond pulsed electric fields induce poly(ADP-ribose) formation and non-apoptotic cell death in HeLa S3 cells.
Biochemical and Biophysical Research Communications, Vol 438, pp 557-562, 2013
Keiko Morotomi-Yano, Hidenori Akiyama, Ken-ichi Yano
Nanosecond pulsed electric fields activate AMP-activated protein kinase: Implications for calcium-mediated activation of cellular signaling.
Biochemical and Biophysical Research Communications, Vol 428, pp 371-375, 2012
Keiko Morotomi-Yano, Seiichi Oyadomari, Hidenori Akiyama, Ken-ichi Yano
Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2alpha phosphorylation and 4E-BP1 dephosphorylation.
Experimental Cell Research, Vol 318, pp 1733-1744, 2012
Keiko Morotomi-Yano, Hidenori Akiyama, Ken-ichi Yano
Nanosecond pulsed electric fields activate MAPK pathways in human cells.
Archives of Biochemistry and Biophysics, Vol 515, pp 99-106, 2011
Keiko Morotomi-Yano, Yuichi Uemura, Sunao Katsuki, Hidenori Akiyama, Ken-ichi Yano
Activation of the JNK pathway by nanosecond pulsed electric fields.
Biochemical and Biophysical Research Communications, Vol 408, pp 471-476, 2011
Selected Presentations
Ken-ichi Yano
Ultrashort electric pulse as a novel physical method for medicine
International Conference on Health Innovation 2023, Surabaya, Indonesia, July 26, 2023
Invited talk
Koki Mochizuki, Tsubasa Koga, Keiko Morotomi-Yano, Ken-ichi Yano
Activation of neutrophils by nanosecond pulsed electric fields
19th International Conference on Flow Dynamics, Sendai, Miyagi, November 9, 2022
Ken-ichi Yano and Keiko Morotomi-Yano
Molecular mechanisms for cell death induction by nanosecond pulsed electric fields -
13rd International Conference on Flow Dynamics (ICFD2016), Sendai, Japan, Oct 11, 2016
Invited talk
Ken-ichi Yano and Keiko Morotomi-Yano
Molecular mechanisms underlying cellular responses to nanosecond pulsed electric fields -
1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies, Portoroz, Slovenia, Sep 7, 2015
Plenary talk
Ken-ichi Yano and Keiko Morotomi-Yano
Physiological significance of calcium in cellular responses to nanosecond pulsed electric fields -
The Annual Meeting of Bioelectromagnetics Society European Bioelectromagnetics Association (BioEM 2015), Pacific Grove, CA, USA, June 19, 2015
Plenary talk
Ken-ichi Yano and Keiko Morotomi-Yano
Molecular basis of cellular responses to nanosecond pulsed electric fields - signal transduction, stress response, and cell death -
11th International Conference on Flow Dynamics, Sendai, Japan, Oct 10, 2014
Plenary talk
Ken-ichi Yano and Keiko Morotomi-Yano
Molecular mechanisms underlying cellular responses to nanosecond pulsed electric fields - Signal transduction, stress response, and cell death -
International Workshop on Diagnostics and Modelling for Plasma Medicine (DMPM2014), Nara, Japan, May 23, 2014
Invited talk
Ken-ichi Yano and Keiko Morotomi-Yano
Adaptive responses of human cells to nanosecond pulsed electric fields
Bioelectrochemistry 2013 (12th Topical Meeting of the International Society of Electrochemistry & XXII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society), Bochum, Germany, Mar 19, 2013
Plenary talk
Ken-ichi Yano
Nanosecond pulsed electric fields act as a novel form of cellular stress to induce translational suppression in human cells.
Gordon Research Conference on Bioelectrochemistry, Lucca, Italy, Jul 2, 2012
Invited talk
Ken-ichi Yano and Keiko Morotomi Yano
Molecular mechanism underlying biological responses to nanosecond pulsed electric fields.
International Bioelectrics Symposium 2011, Toulouse, France, May 5, 2011
Plenary talk
Ken-ichi Yano, Keiko Morotomi-Yano, and David J. Chen
Real-time imaging reveals a novel view of protein assembly in the non-homologous end-joining pathway.
The 56th Annual Meeting of the Radiation Research Society, Maui, Hawaii, USA, Sep 28, 2010
Invited talk
