Prof. Ken-ichi Yano, Prof. Hirofumi Kai, Prof. Shoen Kume,
 Prof. Norio Iriguchi, Assoc. Prof. Yuki Hayashida

The Division of Medical Bioelectrics comprises a multidisciplinary group of scientists who are actively involved in a broad range of research fields. We have a particular interest in integration of new technological advancements including pulse power technologies into the fields of medical sciences. Our major research interests include molecular mechanism of diseases, such as cancer, stem cell biology, magnetic resonance imaging and neuroengineering.

  1. Yano, K., Morotomi-Yano, K., Adachi, K., Akiyama, H. Molecular mechanism of protein assembly on DNA double-strand breaks in the non-homologous end-joining pathway. J. Rad. Res. in press.
  2. Yoshida, T., Murata, K., Shiraki, N., Kume, K., Kume, S. Analysis of gene expressions of ES-derived Pdx1-expressing cells: Implications of genes involved in pancreas differentiation. Develop. Growth Differ. in press.
  3. Saglam, M., Hayashida, Y., Murayama, N. (2009) A retinal circuit model accounting for wide-field amacrine cells. Cognitive Neurodynamics 3, 25-32.
  4. Yano, K., Morotomi-Yano, K., Akiyama, H. (2009) Cernunnos/XLF: A new player in DNA double-strand break repair. Intl. J. Biochem. Cell Biol. 41, 1237-1240.
  5. Furuta, T., Shuto, T., Shimasaki, S., Ohira, Y., Suico, M.A., Gruenert, D.C., Kai, H. (2008) DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription. BMC Mol. Biol. 9, 39.
  6. Hashimoto, Y., Okiyoneda, T., Harada, K., Keiko Ueno, Sugahara, T., Yamashita, A., Shuto, T., Suico, M.A., Kai, H. (2008) Phosphatidic acid metabolism regulate the intracellular trafficking and retrotranslocation of cystic fibrosis transmembrane conductance regulator. BBA-Mol. Cell. Res. 1783, 153-162.
  7. Hidaka, M., Nagata, M., Kawano, Y., Sekiya, H., Kai, H., Yamasaki, K., Okumura, M., Arimori, K. (2008) Inhibitory effects of fruit juices on cytochrome P450 2C9 activity in vitro. Biosci. Biotechnol. Biochem. 72, 406-411.
  8. Iwakiri, T., Okumura, M., Matsunaga, N., Ichihara, E., Shiotsuki, S., Nagata, M., Kumagai, Y., Kai, H., Arimori, K. (2008) Hepatocyte growth factor increases uptake of estradiol 17beta-d-glucuronide and Oatp1 protein level in rat hepatocytes. Eur. J. Pharmacol. 580, 19-26.
  9. Kim, J., Motomiya, Y., Ueda, M., Nakamura, M., Misumi, Y., Saito, S., Ikemizu, S., Misumi, S., Ota, K., Shinriki, S., Kai, H. Ando, Y. (2008) Role of conformational change in the C-terminus of β2-microglobulin in dialysis-related amyloidosis. Ann. Clin. Biochem. 45, 489-495.
  10. Koga, T., Lim, J.H., Jono, H., Ha, U.H., Xu, H., Ishinaga, H., Morino, S., Xu, X., Yan, C., Kai, H., Li, J.D. (2008) Tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J. Biol. Chem. 283, 12546-12554.
  11. Komatsu, K., Jono, H., Lim, J.H., Imasato, A., Xu, H., Kai, H., Yan, C., Li, J.D. (2008) Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK. Biochem. Biophys. Res. Commun. 377, 763-768 .
  12. Morino, S., Kondo, T., Sasaki, K., Adachi, H., Suico, M.A., Sekimoto, E., Matsuda, T., Shuto, T., Araki, E. Kai, H. (2008) Mild Electrical Stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling: Increases ubiquitinated proteins and Hsp72 in A549 cells via attenuation of proteasomal degradation. PLoS ONE 3, e4068.
  13. Morino, S., Suico, M.A., Kondo, T., Sekimoto, E., Yano, S., Matsuda, T., Matsuno, T., Shuto, T., Araki, E., Kai, H. (2008) Mild Electrical Stimulation Increases Ubiquitinated Proteins and Hsp72 in A549 Cells via Attenuation of Proteasomal Degredation. J. Pharmacol. Sci. 108, 222-226.
  14. Motomura, T., Hayashida, Y., Murayama, N. (2008) Spontaneous voltage transients in mammalian retinal ganglion cells dissociated by vibration. In Neural Information Processing, eds. M. Ishikawa et al., Berlin Heidelberg: Springer-Verlag, LNCS 4984 (part 1), pp.64-72.
  15. Murakami, T. Harada, H., Suico, M.A., Shuto, T., Suzu, S., Kai, H., Okada, S. (2008) Ephedrae Herba, a component of Japanese herbal medicine mao-to, efficiently activates the replication of latent human immunodeficiency virus type 1 (HIV-1) in a monocytic cell line. Biol. Pharm. Bull. 31, 2334-2337.
  16. Oba, M., Yano, S., Shuto, T., Suico, M.A., Eguma, A., Kai, H. (2008) Interferon-gamma down-regulated Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo. Int. J. Oncol. 32, 1317-1324.
  17. Okiyoneda, T., Niibori, A., Harada, K., Kohno, T., Michalak, M., Duszyk, M., Wada, I., Ikawa, M., Shuto, T., Suico, M.A, Kai, H. (2008) Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DF508 CFTR. BBA?Mol. Cell Res.1783, 1585-1594.
  18. Saglam, M., Hayashida, Y., Murayama, N. (2008) A retinal circuit model accounting for functions of amacrine cells. In Neural Information Processing, eds. M. Ishikawa et al., Berlin Heidelberg: Springer-Verlag, LNCS 4984 (part 1), pp.1-6.
  19. Saglam, M., Matsunaga, K., Hayashida, Y., Murayama, N., Nakanishi, R. (2008) The effects of theta burst transcranial magnetic stimulation over the human primary motor and sensory cortices on cortico-muscular coherence. In Neural Information Processing, eds. M. Ishikawa et al., Berlin Heidelberg: Springer-Verlag, LNCS 4984 (part 1), pp.135-141.
  20. Saglam, M., Matsunaga, K., Murayama, N., Hayashida, Y., Huang, Y.Z., Nakanishi, R. (2008) Parallel inhibition of cortico-muscular synchronization and cortico-spinal excitability by theta burst TMS in humans. Clin. Neurophysiol. 119, 2829-2838.
  21. Sato, T., Susuki, S., Miyata, M., Ando, Y., Shuto, T., Ann Suico, M.A., Kai, H. (2008) Inhibition of intracellular tetramerization induces the proteasomal degradation of amyloidogenic transthyretin variants.XIth International Symposium on Amyloidosis (Edited by M.Skinner, J.L. Berk, L.H. Connors, D.C. Seldin) CRC Press pp188-190.
  22. Seo, T., Ishitsu, T., Oniki, K., Abe, T., Shuto, T., Nakagawa, K. (2008) ABCC2 haplotype is not associated with drug-resistant epilepsy but with mental retardation. J. Pharm. Pharmacol. 60, 631-635.
  23. Shiraki, N., Higuchi, Y., Harada, S., Umeda, K., Isagawa, T., Aburatani, H., Kume, K., Kume, S. Differentiation and characterization of embryonic stem cells into three germ layers. Biochem. Biophys. Res. Comm. 381, 694-699.
  24. Shiraki, N., Umeda, K., Sakashita, N., Takeya, M., Kume, K. Kume, S. (2008) Differentiation of mouse and human ES cells into hepatic lineages. Genes Cells 13, 731-746, 2008.
  25. Shiraki, N., Yoshida, T., Araki, K., Umezawa, A., Higuchi, Y., Goto, H., Kume, K., Kume, S. (2008) Guided differentiation of ES cells into Pdx1-expressing regional specific definitive endoderm. Stem Cells 26, 874-885.
  26. Susuki, S., Ando, Y., Sato, T., Nishiyama, M., Miyata, M., Suico, MA., Shuto, T., Kai, H. (2008) Multi-elemental analysis of serum and amyloid fibrils in familial amyloid polyneuropathy patients. Amyloid (J. Protein Fold. Disorders) 15, 108-116.
  27. Suwa, Y., Nakamura, T., Toma, S., Ikemizu, S., Kai, H., Yamagata, Y., (2008) Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64, 171-174.
  28. Taura, T., Eguma, A., Suico, M.A., Shuto, T., ?Koga, T., Komatsu, K., Komune, T., Sato, T., Saya, H., Li, J.D., Kai, H. (2008) p53 regulates TLR3 expression and function in human?epithelial cell lines. Mol. Cell. Biol. 28, 6557-6567.
  29. Ueno, K., Koga, T., Kato, K., Golenbock, D.T., Gendler, S.J., Kai, H., Kim, K.C. (2008) MUC1 mucin is a negative regulator of toll-like receptor signaling. Am. J. Respir. Cell Mol. Biol. 38, 263-268.
  30. Yoshida, T., Shiraki, N., Baba, H., Goto, M., Fujiwara, S., Kume, K., Kume, S. (2008) The expression patterns of Epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas. Genes Cells 13, 667-678.
  31. Chirifu, M., Hayashi, C., Nakamura, T., Toma, S., Shuto, T., Kai, H., Yamagata, Y., Davis, S.J., Ikemizu, S. (2007) Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans. Nature Immunol. 8, 1001-1007.
  32. Harada, H., Murakami, T., Tea, S.S., Takeuchi, A., Koga, T., Okada, S., Suico, M.A., Shuto, T., Kai, H. (2007) Heat shock suppresses human NK cell cytotoxicity via regulation of perforin. Intl. J. Hyperthermia 23, 657-665.
  33. Harada, K., Okiyoneda, T., Hashimoto, Y., Oyokawa, K., Nakamura, K., Suico, M.A., Shuto, T., Kai, H. (2007) Curucumin enhances cystic fibrosis transmembrane regulator expression by down-regulating calreticuline. Biochem. Biophys. Res. Commun. 353, 351-356.
  34. Huang, Y., Mikami, F., Jono, H., Zhang, W., Weng, X., Koga, T., Xu, H., Yan, C., Kai, H., Li, J.D. (2007) Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF. Biochem. Biophys. Res. Commun. 359, 691-696.
  35. Kato, K., Lu, W., Kai, H., Kim, K.C. (2007) Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of TLR5 signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 293, L686-692.
  36. Mat Safri, N. Murayama, N., Hayashida, Y., Igasaki, T. (2007) Effects of concurrent visual tasks on cortico-muscular synchronization in humans. Brain Res. 1155, 81-92.
  37. Motomura, T., Hayashida, Y., Murayama, N. (2007) Mechanical dissociation of retinal neurons with vibration. IEEJ Transactions on Electronics, Information and Systems C, 127, 1603-1610. [in Japanese]
  38. Sakai, A., Koga, T., Lim, J.H., Jono, H., Harada, K., Szymanski, E., Xu, H., Kai, H., Li, J.D. (2007) The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression: Evidence for negative regulation of host anti-viral response by CYLD. FEBS J. 274, 3655-3668.
  39. Sato, T., Susuki, S., Suico, M.A., Miyata, M., Ando, Y., Mizuguchi, M., Takeuchi, M., Dobashi, M., Shuto, T., Kai, K., (2007) Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell. EMBO J. 26, 2501-2512.
  40. Shuto, T., Furuta, T., Cheung, J., Gruenert, D.C., Ohira, Y., Shimasaki, S., Suico, M.A., Sato, K., Kai, H. (2007) Increased responsiveness to TLR2 and TLR4 ligands during dimethylsulfoxide-induced neutrophil-like differentiation of HL-60 myeloid leukemia cells. Leukemia Res. 31, 1721-1728.